|
Symbol Name ID |
Notch1
notch 1 MGI:97363 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Gastrointestinal hemorrhage |
Portal vein thrombosis |
Right atrial enlargement |
Atrial septal defect |
Patent foramen ovale |
Ventricular septal defect |
Right ventricular hypertrophy |
Mitral atresia |
Double outlet right ventricle |
Tetralogy of Fallot |
Bicuspid aortic valve |
Aortic valve calcification |
Abnormal pulmonary valve morphology |
Hypoplastic left heart |
Pulmonary artery atresia |
Pulmonary artery stenosis |
Patent ductus arteriosus |
Arteriovenous malformation |
Aortic valve stenosis |
Mitral stenosis |
Pulmonic stenosis |
Hypertension |
Portal hypertension |
Pulmonary arterial hypertension |
Splenomegaly |
Hypersplenism |
Cavernous hemangioma |
Cutis marmorata |
| Disease(s) Associated with NOTCH1 | ||||||||||||||||||||||||||||
| Adams-Oliver syndrome | ||||||||||||||||||||||||||||
| aortic valve disease 1 |
| Mouse Phenotypes | cardiovascular system phenotype |
abnormal artery morphology |
abnormal dorsal aorta morphology |
abnormal retina blood vessel morphology |
abnormal intersomitic vessel morphology |
dilated liver sinusoidal space |
abnormal placenta vasculature |
abnormal placental labyrinth vasculature morphology |
abnormal vascular development |
abnormal angiogenesis |
abnormal vascular branching morphogenesis |
abnormal anterior cardinal vein morphology |
decreased angiogenesis |
increased angiogenesis |
abnormal vasculogenesis |
abnormal vitelline vasculature morphology |
absent vitelline blood vessels |
abnormal myocardium layer morphology |
trabecula carnea hypoplasia |
thin myocardium compact layer |
disorganized myocardium |
myocardium hypoplasia |
thin myocardium |
abnormal cardiac epithelial to mesenchymal transition |
abnormal heart development |
delayed heart looping |
abnormal coronary vessel morphology |
absent coronary vessels |
calcified aortic valve cusp |
thick aortic valve cusps |
hemopericardium |
abnormal epicardium morphology |
distended pericardium |
pericardial effusion |
hemorrhage |
internal hemorrhage |
hemoperitoneum |
aortic valve inflammation |
cornea vascularization |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||
| Notch1sot/Notch1sot | ||||||||||||||||||||||||||||||||||||||||
| Notch1tm1Con/Notch1tm1Con | ||||||||||||||||||||||||||||||||||||||||
| Notch1tm1Grid/Notch1tm1Grid | ||||||||||||||||||||||||||||||||||||||||
| Notch1tm1Rko/Notch1tm1Rko | ||||||||||||||||||||||||||||||||||||||||
| Notch1tm2Agt/Notch1tm2Agt | ||||||||||||||||||||||||||||||||||||||||
| Notch1tm1Con/Notch1+ | * | |||||||||||||||||||||||||||||||||||||||
| Notch1tm1Grid/Notch1+ | ||||||||||||||||||||||||||||||||||||||||
| Notch1tm2Pst/Notch1tm2.1Pst | ||||||||||||||||||||||||||||||||||||||||
| Notch1tm1Agt/Notch1tm1Agt Tg(Tek-cre)1Ywa/0 (conditional) |
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| Notch1tm1Agt/Notch1tm1Agt Tg(Tek-cre)12Flv/0 (conditional) |
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| Notch1tm1Agt/Notch1tm1Agt Tg(Wt1-cre)#Jbeb/0 (conditional) |
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| Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+ Tg(Wt1-cre)#Jbeb/0 (conditional) |
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| Notch1tm1Con/Notch1tm1Grid Tg(Pax2-cre)1Akg/0 (conditional) |
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| Notch1tm2Rko/Notch1tm3(cre)Rko (conditional) | ||||||||||||||||||||||||||||||||||||||||
| Notch1tm2Rko/Notch1tm4(cre)Rko (conditional) | ||||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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